Article
Gene, region and pathway level analyses in whole-genome studies.
Genetic epidemiology - 1 Apr 2010
De la Cruz Omar, Wen Xiaoquan, Ke Baoguan, Song Minsun, Nicolae Dan L
Abstract excerpt
In the setting of genome-wide association studies, we propose a method for assigning a measure of significance to pre-defined sets of markers in the genome. The sets can be genes, conserved regions, or groups of genes such as pathways. Using the proposed methods and algorithms, evidence for association between a particular functional unit and a disease status can be obtained not just by the presence of a strong...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.