Article
GSEA-SNP: applying gene set enrichment analysis to SNP data from genome-wide association studies.
Bioinformatics (Oxford, England) - 1 Dec 2008
Holden Marit, Deng Shiwei, Wojnowski Leszek, Kulle Bettina
Abstract excerpt
The power of genome-wide SNP association studies is limited, among others, by the large number of false positive test results. To provide a remedy, we combined SNP association analysis with the pathway-driven gene set enrichment analysis (GSEA), recently developed to facilitate handling of genome-wide gene expression data. The resulting GSEA-SNP method rests on the assumption that SNPs underlying a disease...
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