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Article

Functional dissection of an IFN-alpha/beta receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection.

Journal of hepatology - 1 Aug 2009

Zhou Jie, Huang Jian-Dong, Poon Vincent K M, Chen Ding-Qiang, Chan Chris C S, Ng Fai, Guan Xin-Yuan, Watt Rory M, Lu Liwei, Yuen Kwok-Yung, Zheng Bo-Jian

Abstract excerpt

BACKGROUND/AIMS: We previously demonstrated that two linked single nucleotide polymorphisms (SNPs) at -408 and -3 of type I interferon receptor 1 (IFNAR1) promoter are associated with susceptibility to chronic HBV infection. We aimed to elucidate the mechanism by which -3 and/or -408 C/T SNPs had such profound effects. METHODS: A functional SNP in IFNAR1 promoter was defined by reporter gene assay, mutational...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19501422
DOI: 10.1016/j.jhep.2009.03.020

Genes

IFNAR1
HMGB1

Provenance

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