Article
A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection.
Immunogenetics - 1 Jun 2009
Zhou Jie, Chen Ding-Qiang, Poon Vincent K M, Zeng Yong, Ng Fai, Lu Liwei, Huang Jian-Dong, Yuen Kwok-Yung, Zheng Bo-Jian
Abstract excerpt
The antiviral cascade triggered by interferon-gamma (IFN-gamma) represents a vital event for eradicating hepatitis B virus (HBV) in experimental animals. IFN-gamma signaling is mediated through the ligand binding to IFN-gamma receptor 1 (IFNGR1). Control of IFNGR1 expression level is one of the mechanisms by which cells modulate the potency of IFN-gamma signaling. In this study, we comprehensively investigated...
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