Article
Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors.
Developmental cell - 23 Mar 2020
Seymour Philip Allan, Collin Caitlin Alexis, Egeskov-Madsen Anuska la Rosa, Jørgensen Mette Christine, Shimojo Hiromi, Imayoshi Itaru, de Lichtenberg Kristian Honnens, Kopan Raphael, Kageyama Ryoichiro, Serup Palle
Abstract excerpt
Notch signaling controls proliferation of multipotent pancreatic progenitor cells (MPCs) and their segregation into bipotent progenitors (BPs) and unipotent pro-acinar cells (PACs). Here, we showed that fast ultradian oscillations of the ligand Dll1 and the transcriptional effector Hes1 were crucial for MPC expansion, and changes in Hes1 oscillation parameters were associated with selective adoption of BP or PAC...
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