Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish.

BMC biology - 8 Jul 2013

Flasse Lydie C, Pirson Justine L, Stern David G, Von Berg Virginie, Manfroid Isabelle, Peers Bernard, Voz Marianne L

Abstract excerpt

BACKGROUND: NEUROG3 is a key regulator of pancreatic endocrine cell differentiation in mouse, essential for the generation of all mature hormone producing cells. It is repressed by Notch signaling that prevents pancreatic cell differentiation by maintaining precursors in an undifferentiated state. RESULTS: We show that, in zebrafish, neurog3 is not expressed in the pancreas and null neurog3 mutant embryos do not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Zebrafish Proteins
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Nonmammalian

Share to Gene Knockdown Techniques

Share to HMGB Proteins

Share to Morpholinos

Share to Pancreas

Share to Receptors, Notch

Source

Open in PubMed Open full text

Identifiers

PMID: 23835295
DOI: 10.1186/1741-7007-11-78
PMCID: PMC3726459

Genes

NEUROG3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish.PMID 23835295Read ↗

Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas.Semantic proximity Read ↗

Minireview: Development and Differentiation of Gut Endocrine CellsSemantic proximity Read ↗

Basic helix‐loop‐helix transcription factors and enteroendocrine cell differentiationSemantic proximity Read ↗

The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas.Semantic proximity Read ↗

NEUROD1 Is Required for the Early α and β Endocrine Differentiation in the PancreasSemantic proximity Read ↗

The bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine.Semantic proximity Read ↗

Induction of pancreatic islet cell differentiation by the neurogenin–neuroD cascadeSemantic proximity Read ↗

Neurogenin3 Cooperates with Foxa2 to Autoactivate Its Own ExpressionSemantic proximity Read ↗

Development of the Human Pancreas From Foregut to Endocrine CommitmentSemantic proximity Read ↗

Endoderm Jagged induces liver and pancreas duct lineage in zebrafishSemantic proximity Read ↗

Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity.Semantic proximity Read ↗

Mind bomb 1 is required for pancreatic β-cell formation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.