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Article

Premature aging in vitamin D receptor mutant mice.

The Journal of steroid biochemistry and molecular biology - 1 Jul 2009

Keisala Tiina, Minasyan Anna, Lou Yan-Ru, Zou Jing, Kalueff Allan V, Pyykkö Ilmari, Tuohimaa Pentti

Abstract excerpt

Hypervitaminosis vitamin D(3) has been recently implicated in premature aging through the regulation of 1alpha hydroxylase expression by klotho and fibroblast growth factor-23 (Fgf-23). Here we examined whether the lack of hormonal function of vitamin D(3) in mice is linked to aging phenomena. For this, we used vitamin D(3) receptor (VDR) "Tokyo" knockout (KO) mice (fed with a special rescue diet) and analyzed...

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Source

Identifiers

PMID: 19500727
DOI: 10.1016/j.jsbmb.2009.03.007

Genes

VDR
IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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