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Article

Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2006

Razzaque Mohammed S, Sitara Despina, Taguchi Takashi, St-Arnaud René, Lanske Beate

Abstract excerpt

Fibroblast growth factor 23 null mice (Fgf-23-/-) have a short lifespan and show numerous biochemical and morphological features consistent with premature aging-like phenotypes, including kyphosis, severe muscle wasting, hypogonadism, osteopenia, emphysema, uncoordinated movement, T cell dysregulation, and atrophy of the intestinal villi, skin, thymus, and spleen. Furthermore, increased vitamin D activities in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16436465
DOI: 10.1096/fj.05-5432fje
PMCID: PMC2899884

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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