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Article

Excitotoxic-mediated transcriptional decreases in HCN2 channel function increase network excitability in CA1.

Experimental neurology - 1 Sept 2009

Adams Brendan E L, Reid Christopher A, Myers Damian, Ng Caroline, Powell Kim, Phillips A Marie, Zheng Thomas, O'Brien Terence J, Williams David A

Abstract excerpt

Changes in the conductance of the hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel that mediates Ih are proposed to contribute to increased network excitability. Synchronous neuronal burst activity is a good reflection of network excitability and can be generated in isolated hip...

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Source

Identifiers

PMID: 19500574
DOI: 10.1016/j.expneurol.2009.05.030

Genes

HCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19500574-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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