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Article

Spike-and-wave discharge mediated reduction in hippocampal HCN1 channel function associates with learning deficits in a genetic mouse model of epilepsy.

Neurobiology of disease - 1 Apr 2014

Phillips A Marie, Kim Taehwan, Vargas Ernesto, Petrou Steven, Reid Christopher A

Abstract excerpt

The GABAAγ2(R43Q) mouse is an established model of absence epilepsy displaying spontaneous spike-and-wave discharges (SWD) and associated behavioral arrest. Absence epilepsy typically results from cortico-thalamic networks. Nevertheless, there is increasing evidence for changes in hippocampal metabolism and electrical behavior, consistent with a link between absence seizures and hippocampus-related...

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Share to CA1 Region, Hippocampal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

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Source

Identifiers

PMID: 24368169
DOI: 10.1016/j.nbd.2013.12.007

Genes

HCN1
HCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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