Article

Lamotrigine Attenuates Neuronal Excitability, Depresses GABA Synaptic Inhibition, and Modulates Theta Rhythms in Rat Hippocampus

2021-11-05

Abstract excerpt

Theta oscillations generated in hippocampal (HPC) and cortical neuronal networks are involved in various aspects of brain function, including sensorimotor integration, movement planning, memory formation and attention. Disruptions of theta rhythms are present in individuals with various disorders, including epilepsy and Alzheimer’s disease. Theta rhythm generation involves a specific interplay between cellul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fb63448b-b042-5482-9bdf-11bf48b1646a
DOI: 10.20944/preprints202111.0067.v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lamotrigine Attenuates Neuronal Excitability, Depresses GABA Synaptic Inhibition, and Modulates Theta Rhythms in Rat HippocampusDOI 10.20944/preprints202111.0067.v2Read

Excitotoxic-mediated transcriptional decreases in HCN2 channel function increase network excitability in CA1.Semantic proximity Read

Cav2.3 (R-Type) Calcium Channels are Critical for Mediating Anticonvulsive and Neuroprotective Properties of Lamotrigine In Vivo.Semantic proximity Read

Long-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic miceSemantic proximity Read

Reduction of glutamatergic activity through cholinergic dysfunction in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout miceSemantic proximity Read

Ketamine can produce oscillatory dynamics by engaging mechanisms dependent on the kinetics of NMDA receptorsSemantic proximity Read

Selective Alterations in GABA<sub>A</sub>Receptor Subtypes in Human Temporal Lobe EpilepsySemantic proximity Read

Distinct electrophysiological properties of glutamatergic, cholinergic and GABAergic rat septohippocampal neurons: novel implications for hippocampal rhythmicity.Semantic proximity Read

Oscillations in the Dentate Gyrus as a Tool for the Functioning of the Hippocampus: Healthy and Epileptic BrainSemantic proximity Read

Post-Ictal Gamma Oscillations Predict Hippocampal Structural Integrity in Mesial Temporal Lobe EpilepsySemantic proximity Read

Axonal theta oscillations evoke bursting in target hippocampal subregionsSemantic proximity Read

Riluzole activates TRPC5 channels independently of PLC activity.Semantic proximity Read

Interaction between theta-phase and spike-timing dependent plasticity simulates theta induced memory effectsSemantic proximity Read