Article
Delivery of sry1, but not sry2, to the kidney increases blood pressure and sns indices in normotensive wky rats.
BMC physiology - 5 Jun 2009
Ely Daniel, Milsted Amy, Dunphy Gail, Boehme Shannon, Dunmire Jeff, Hart Mike, Toot Jonathon, Turner Monte
Abstract excerpt
BACKGROUND: Our laboratory has shown that a locus on the SHR Y chromosome increases blood pressure (BP) in the SHR rat and in WKY rats with the SHR Y chromosome (SHR/y rat). A candidate for this Y chromosome hypertension locus is Sry, a gene that encodes a transcription factor responsible for testes determination. The SHR Y chromosome has six divergent Sry loci. The following study examined if exogenous Sry1 or...
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