Article
Differential baseline and response profile to IFN-gamma gene transduction of IL-6/IL-6 receptor-alpha secretion discriminate primary tumors versus bone marrow metastases of nasopharyngeal carcinomas in culture.
BMC cancer - 5 Jun 2009
Chou Andy Shau-Bin, Wang Hsin-Yi, Chen Hung-Chang, Tsai Ming-Hsiu, Chuang Cheng-Keng, Liao Shuen-Kuei
Abstract excerpt
BACKGROUND: Understanding of immunobiology of bone marrow metastases (designated BM-NPC) versus primary tumors (P-NPC) of the nasopharynx is far from complete. The aim of this study was to determine if there would be differences between cultured P-NPCs and BM-NPCs with respect to (i) constitutive IL-6 and the IL-6 receptor gp80 subunit (IL-6Ralpha) levels in the spent media of nontransduced cells, and (ii) IL-6...
Topics
- Bone Marrow Neoplasms
- Cell Line, Tumor
- Humans
- Interferon-gamma
- Interleukin-6
- Nasopharyngeal Neoplasms
- Phenotype
- Receptors, Interleukin-6
- Transduction, Genetic
- Tumor Cells, Cultured