Article
Tumor dormancy resulting from subcutaneous injection to SCID mice with cultured nasopharyngeal carcinoma cells is mediated via IFN-γ induction of a highly differentiated phenotype.
Cancer biotherapy & radiopharmaceuticals - 1 Aug 2011
Chou Andy Shau-Bin, Chen Hung-Chang, Li Chia-Rui, Hsieh Chin-Hsuan, Ting Lai-Lei, Liao Shuen-Kuei
Abstract excerpt
The mechanisms underlying tumor dormancy in human primary lesions and bone marrow metastases of nasopharyngeal carcinoma (NPC) are still not completely understood. The aim of this study was to determine differences in the fates of cultured primary NPC (P-NPC) cells, interferon-γ-transduced primary NPC (IFN-γ-P-NPC) cells, bone marrow metastatic NPC (BM-NPC), and IFN-γ-transduced BM-NPC (IFN-γ-BM-NPC) cells...
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