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Article

Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2009

Romieu-Mourez Raphaëlle, François Moïra, Boivin Marie-Noëlle, Bouchentouf Manaf, Spaner David E, Galipeau Jacques

Abstract excerpt

Bone marrow-derived mesenchymal stromal cells (MSC) possess an immune plasticity manifested by either an immunosuppressive or, when activated with IFN-gamma, an APC phenotype. Herein, TLR expression by MSC and their immune regulatory role were investigated. We observed that human MSC and macrophages expressed TLR3 and TLR4 at comparable levels and TLR-mediated activation of MSC resulted in the production of...

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Source

Identifiers

PMID: 19494321
DOI: 10.4049/jimmunol.0803864

Genes

MSC
APC
CCL5
CXCL8
TLR3
TLR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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