Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Toll-like receptor-3-activated human mesenchymal stromal cells significantly prolong the survival and function of neutrophils.

Stem cells (Dayton, Ohio) - 1 Jun 2011

Cassatella Marco A, Mosna Federico, Micheletti Alessandra, Lisi Veronica, Tamassia Nicola, Cont Caterina, Calzetti Federica, Pelletier Martin, Pizzolo Giovanni, Krampera Mauro

Abstract excerpt

Bone marrow-derived mesenchymal stromal cells (BM-MSCs) are stromal precursors endowed with extensive immunomodulative properties. In this study, we aimed to assess whether Toll-like receptor-3 (TLR3)- and TLR4-activated BM-MSC influence human neutrophil (PMN) responses under coculture conditions. We show that TLR3 triggering by polyinosinic:polycytidylic acid dramatically amplifies, in a more significant manner...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coculture Techniques
Share to Culture Media, Conditioned

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Granulocyte Colony-Stimulating Factor

Share to Interferon-beta

Share to Mesenchymal Stem Cells

Share to Neutrophils

Share to Poly I-C

Share to Toll-Like Receptor 3

Source

Identifiers

PMID: 21563279
DOI: 10.1002/stem.651

Genes

MSC
TLR3
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Toll-like receptor-3-activated human mesenchymal stromal cells significantly prolong the survival and function of neutrophils.PMID 21563279Read ↗

A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype.Semantic proximity Read ↗

Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype.Semantic proximity Read ↗

The immunomodulatory function of mesenchymal stem cells: mode of action and pathwaysSemantic proximity Read ↗

Human mesenchymal stem cells shift CD8+ T cells towards a suppressive phenotype by inducing tolerogenic monocytes.Semantic proximity Read ↗

Toll-like receptor-mediated signaling in human adipose-derived stem cells: implications for immunogenicity and immunosuppressive potential.Semantic proximity Read ↗

Lysis and phenotypic modulation of mesenchymal stromal cells upon blood contact triggers anti-inflammatory skewing of the peripheral innate immune repertoire.Semantic proximity Read ↗

Immunomodulatory Properties of Mesenchymal Stromal Cells: Still Unresolved “Yin and Yang”Semantic proximity Read ↗

Toll-like receptor triggering in cord blood mesenchymal stem cellsSemantic proximity Read ↗

The significance of the host inflammatory response on the therapeutic efficacy of cell therapies utilising human adult stem cells.Semantic proximity Read ↗

Phenotypic and immunomodulatory properties of equine cord blood-derived mesenchymal stromal cells.Semantic proximity Read ↗

The mechanisms of cellular crosstalk between mesenchymal stem cells and natural killer cells: Therapeutic implications.Semantic proximity Read ↗

Critical roles of TLRs on the polarization of Mesenchymal stem cells for cell therapy of viral infections: A notice for COVID-19 treatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.