Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype.

PloS one - 26 Apr 2010

Waterman Ruth S, Tomchuck Suzanne L, Henkle Sarah L, Betancourt Aline M

Abstract excerpt

BACKGROUND: Our laboratory and others reported that the stimulation of specific Toll-like receptors (TLRs) affects the immune modulating responses of human multipotent mesenchymal stromal cells (hMSCs). Toll-like receptors recognize "danger" signals, and their activation leads to profound cellular and systemic responses that mobilize innate and adaptive host immune cells. The danger signals that trigger TLRs are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coculture Techniques
Share to Immune System

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunity

Share to Mesenchymal Stem Cells

Share to Monocytes

Share to Toll-Like Receptor 3

Share to Toll-Like Receptor 4

Share to Toll-Like Receptors

Source

Open in PubMed Open full text

Identifiers

PMID: 20436665
DOI: 10.1371/journal.pone.0010088
PMCID: PMC2859930

Genes

TLR3
TLR4
MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype.PMID 20436665Read ↗

Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype.Semantic proximity Read ↗

Critical roles of TLRs on the polarization of Mesenchymal stem cells for cell therapy of viral infections: A notice for COVID-19 treatmentSemantic proximity Read ↗

Mesenchymal Stem Cells Direct the Immunological Fate of Macrophages.Semantic proximity Read ↗

The Secretome of Preconditioned Mesenchymal Stem Cells Drives Polarization and Reprogramming of M2a Macrophages toward an IL-10-Producing Phenotype.Semantic proximity Read ↗

Mesenchymal Stromal Cells Affect Disease Outcomes via Macrophage PolarizationSemantic proximity Read ↗

The immunomodulatory function of mesenchymal stem cells: mode of action and pathwaysSemantic proximity Read ↗

Toll-like receptor-3-activated human mesenchymal stromal cells significantly prolong the survival and function of neutrophils.Semantic proximity Read ↗

Human amnion favours tissue repair by inducing the M1-to-M2 switch and enhancing M2 macrophage features.Semantic proximity Read ↗

Revisiting the Mesenchymal “Stem vs. Stromal” Cell Dichotomy and Its Implications for Development of Improved Potency MetricsSemantic proximity Read ↗

Insights into inflammatory priming of mesenchymal stromal cells: functional biological impacts.Semantic proximity Read ↗

The Role of Mesenchymal Stem/Stromal Cells Secretome in Macrophage Polarization: Perspectives on Treating Inflammatory DiseasesSemantic proximity Read ↗

Immunoregulatory function of mesenchymal stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.