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Article

Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice.

Neurobiology of aging - 1 Oct 2008

Wu Pu, Shen Qian, Dong Suzhen, Xu Zhiliang, Tsien Joe Z, Hu Yinghe

Abstract excerpt

Conditional double knockout of presenilin-1 and presenilin-2 (cDKO) in forebrain of mice led to brain atrophy, tau hyperphosphorylation, synaptic dysfunction and cognitive deficit. These brain changes recapitulated most of the neurodegenerative phenotypes of Alzheimer's disease (AD). In this report, we have investigated the effects of 4-month calorie restriction (CR) regimen on different phenotypes in cDKO mice....

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Identifiers

PMID: 17499883
DOI: 10.1016/j.neurobiolaging.2007.03.028

Genes

CDK5

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