Article
Association of the leukocyte immunoglobulin G (Fcgamma) receptor IIIa-158V/F polymorphism with inflammatory myopathies in Dutch patients.
Tissue antigens - 1 Jun 2009
Bronner I M, Hoogendijk J E, de Visser M, van de Vlekkert J, Badrising U A, Wintzen A R, Uitdehaag B M J, Blokland-Fromme M, Leusen J H W, van der Pol W-L
Abstract excerpt
Leukocytes are involved in the pathogenesis of idiopathic inflammatory myopathies (IIMs). Immunoglobulin G (IgG) receptors (FcgammaR) link the specificity of IgG to the effector functions of leukocytes. Several FcgammaR subclasses display functional polymorphisms that determine in part the vigour of the inflammatory response. FcgammaRIIIa genotypes were differentially distributed among 100 IIM patients compared...
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