Article
Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms.
Journal of neuroimmunology - 1 May 2005
van Sorge Nina M, van der Pol W-Ludo, Jansen Marc D, Geleijns Karin P W, Kalmijn Sandra, Hughes Richard A C, Rees Jeremy H, Pritchard Jane, Vedeler Christian A, Myhr Kjell-Morten, Shaw Chris, van Schaik Ivo N, Wokke John H J, van Doorn Pieter A, Jacobs Bart C, van de Winkel Jan G J, van den Berg Leonard H
Abstract excerpt
Macrophages and ganglioside-specific IgG are involved in the pathogenesis of Guillain-Barre syndrome (GBS). Leukocyte IgG receptors (Fc gammaR) confer potent cellular effector functions to the specificity of IgG. The efficacy of IgG-mediated cellular inflammatory responses is determined by functional polymorphisms of three Fc gammaR subclasses (Fc gammaRIIa: H131/R131; Fc gammaRIIIa: V158/F158; Fc gammaRIIIb:...
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