Article
Association of the Fc gamma receptor IIA-R/R131 genotype with myasthenia gravis in Dutch patients.
Journal of neuroimmunology - 1 Nov 2003
van der Pol W L, Jansen M D, Kuks J B M, de Baets M, Leppers-van de Straat F G J, Wokke J H J, van de Winkel J G J, van den Berg L H
Abstract excerpt
Myasthenia gravis (MG) susceptibility is partially determined by allelic heterogeneity of immune-modulatory genes. IgG receptors (FcgammaR) link the humoral and cellular branches of the immune system, and regulate immune responses and inflammation. Three FcgammaR subclasses (FcgammaRIIa, FcgammaRIIIa, and FcgammaRIIIb) exhibit functional polymorphisms, which affect efficiency of FcgammaR-mediated functions....
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