Article
Contribution of Fcgamma receptor IIIA gene 158V/F polymorphism and copy number variation to the risk of ACPA-positive rheumatoid arthritis.
Annals of the rheumatic diseases - 1 Nov 2009
Thabet M M, Huizinga T W J, Marques R B, Stoeken-Rijsbergen G, Bakker A M, Kurreeman F A, White S J, Toes R E M, van der Helm-van Mil A H M
Abstract excerpt
BACKGROUND: Fcgamma receptors (FcgammaRs) are potent immune modulators. FcgammaR genes encompass a complex region, polymorphic by both single nucleotide polymorphisms (SNPs) and copy number variation (CNV). The heterogeneity of rheumatoid arthritis (RA) combined with the genetic complexity of FcgammaR genes may be the cause of inconsistent findings in previous RA studies on FcgammaR SNPs. There is increasing...
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