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Article

Analysis of genes within the HLA region affecting susceptibility to ulcerative colitis.

Human immunology - 1 Feb 1993

Sugimura K, Asakura H, Mizuki N, Inoue M, Hibi T, Yagita A, Tsuji K, Inoko H

Abstract excerpt

To clarify the molecular relationship between HLA loci and ulcerative colitis (UC) in Japanese patients, we performed HLA-DP genotyping by the PCR-RFLP method and studied tumor necrosis factor beta-chain genetic polymorphism by Southern hybridization, in addition to conventional serologic typing. Significant increase was observed in Bw52, DPw9 (DPB1*0901), and DR2 (DRB1*1502) in Japanese patients with UC. Linkage...

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Identifiers

PMID: 8096500
DOI: 10.1016/0198-8859(93)90113-f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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