Article
Mapping of a disease susceptibility locus in chromosome 6p in Japanese patients with ulcerative colitis.
Genes and immunity - 1 Sept 2004
Nomura E, Kinouchi Y, Negoro K, Kojima Y, Oomori S, Sugimura M, Hiroki M, Takagi S, Aihara H, Takahashi S, Hiwatashi N, Shimosegawa T
Abstract excerpt
Ulcerative colitis (UC) is a multifactorial disorder with both genetic and environmental factors. HLA-B*52 and DRB1*1502 are reported to be strongly associated with UC in Japan. However, the actual susceptible gene has not been identified yet. In this study, to map precisely the susceptible locus for UC, we performed association mapping in the chromosome 6p using 24 microsatellite markers distributed over 16 Mb....
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