Megakaryocyte ontogeny: Clinical and molecular significance.

doi:10.1016/j.exphem.2018.02.003

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Article

Megakaryocyte ontogeny: Clinical and molecular significance.

Experimental hematology - 1 May 2018

Elagib Kamaleldin E, Brock Ashton T, Goldfarb Adam N

Abstract excerpt

Fetal megakaryocytes (Mks) differ from adult Mks in key parameters that affect their capacity for platelet production. However, despite being smaller, more proliferative, and less polyploid, fetal Mks generally mature in the same manner as adult Mks. The phenotypic features unique to fetal Mks predispose patients to several disease conditions, including infantile thrombocytopenia, infantile megakaryoblastic...

Topics

Fetal Blood
Humans
Megakaryocytes
Models, Biological
Morphogenesis
Phenotype
Thrombocytopenia

Source

Open in PubMed Open full text

Identifiers

PMID: 29501467
DOI: 10.1016/j.exphem.2018.02.003
PMCID: PMC5899671

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