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Article

Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip.

PLoS genetics - 1 May 2009

Spencer Chris C A, Su Zhan, Donnelly Peter, Marchini Jonathan

Abstract excerpt

Genome-wide association studies are revolutionizing the search for the genes underlying human complex diseases. The main decisions to be made at the design stage of these studies are the choice of the commercial genotyping chip to be used and the numbers of case and control samples to be genotype...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19492015
DOI: 10.1371/journal.pgen.1000477
PMCID: PMC2688469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19492015-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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