Article
Degradation of cyclin A is regulated by acetylation.
Oncogene - 23 Jul 2009
Mateo F, Vidal-Laliena M, Canela N, Busino L, Martinez-Balbas M A, Pagano M, Agell N, Bachs O
Abstract excerpt
Cyclin A accumulates at the onset of S phase, remains high during G(2) and early mitosis and is degraded at prometaphase. Here, we report that the acetyltransferase P/CAF directly interacts with cyclin A that as a consequence becomes acetylated at lysines 54, 68, 95 and 112. Maximal acetylation occurs simultaneously to ubiquitylation at mitosis, indicating importance of acetylation on cyclin A stability. This was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.