Article
Global control of histone modification by the anaphase-promoting complex.
Molecular and cellular biology - 1 Dec 2003
Ramaswamy Vijay, Williams Jessica S, Robinson Karen M, Sopko Richelle L, Schultz Michael C
Abstract excerpt
Acetylation and phosphorylation of the amino-terminal tails of the core histones fluctuate on a global scale in concert with other major events in chromosome metabolism. A ubiquitin ligase, the anaphase-promoting complex (APC), controls events in chromosome metabolism such as sister chromatid cohesion and may regulate H3 phosphorylation by targeting Aurora A, one of several S10-directed H3 kinases in vertebrate...
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