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Article

BRCA2 heterozygosity delays cytokinesis in primary human fibroblasts.

Cellular oncology : the official journal of the International Society for Cellular Oncology - 1 Jan 2009

Jonsdottir Asta Björk, Vreeswijk Maaike P G, Wolterbeek Ron, Devilee Peter, Tanke Hans J, Eyfjörd Jorunn E, Szuhai Karoly

Abstract excerpt

BACKGROUND: Inherited mutations in the tumour suppressor gene BRCA2 greatly increase the risk of developing breast, ovarian and other types of cancers. So far, most studies have focused on the role of BRCA-pathways in the maintenance of genomic stability. In this study we investigated the potential role of the BRCA2 protein in cytokinesis in unmodified primary human fibroblast carrying a heterozygous mutation in...

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Source

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Identifiers

PMID: 19478387
DOI: 10.3233/CLO-2009-0465
PMCID: PMC4618909

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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