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Lower level of BRCA2 protein in heterozygous mutation carriers is correlated with an increase in DNA double strand breaks and an impaired DSB repair.

Cancer letters - 8 Nov 2006

Arnold Katrin, Kim Min-Kyoung, Frerk Katrin, Edler Lutz, Savelyeva Larissa, Schmezer Peter, Wiedemeyer Ruprecht

Abstract excerpt

The BRCA2 protein is involved in the maintenance of genomic stability through its key role in homologous recombination repair of DNA double strand breaks. Biallelic inactivation of BRCA2 leads to a defect in DNA repair and is associated with a chromosomal instability phenotype. Recent studies on familial breast cancer clusters revealed chromosomal rearrangements and higher rates of sister chromatid exchanges also...

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Identifiers

PMID: 16448746
DOI: 10.1016/j.canlet.2005.11.041

Genes

BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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