Article
BRCA2 in mitotic exit: a new role in regulating genomic stability.
Future oncology (London, England) - 1 Feb 2006
Wang Xiaoxing, Dai Wei
Abstract excerpt
Evaluation of: Daniels MJ, Wang Y, Lee M, Venkitaraman AR: Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2. Science 306, 876-879 (2004). Cytokinesis is the division of the cytoplasm of a parent cell into daughter cells after nuclear division. Cytokinesis failure is often accompanied by the generation of cells with an unstable tetraploidy content, which predisposes the...
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