Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tetraploidy in BRCA2 breast tumours.

European journal of cancer (Oxford, England : 1990) - 1 Feb 2012

Jonsdottir Asta Bjork, Stefansson Olafur Andri, Bjornsson Johannes, Jonasson Jon G, Ogmundsdottir Helga M, Eyfjord Jorunn E

Abstract excerpt

Tetraploidy and aneuploidy can be caused by cell division errors and are frequently observed in many human carcinomas. We have recently reported delayed cytokinesis in primary human fibroblasts from BRCA2 mutation carriers, implying a function for the BRCA2 tumour suppressor in completion of cell division. Here, we address ploidy aberrations in breast tumours derived from BRCA2 germline mutation carriers. Ploidy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aneuploidy
Share to Breast Neoplasms
Share to Flow Cytometry

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, BRCA2

Share to Genetic Markers

Share to Germ-Line Mutation

Share to Immunohistochemistry

Share to Tetraploidy

Source

Identifiers

PMID: 22133571
DOI: 10.1016/j.ejca.2011.11.008

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tetraploidy in BRCA2 breast tumours.PMID 22133571Read ↗

Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers.Semantic proximity Read ↗

Suppression of polyploidy by the BRCA2 protein.Semantic proximity Read ↗

WEE1 kinase inhibition triggers severe chromosome pulverization in aneuploid cellsSemantic proximity Read ↗

Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation.Semantic proximity Read ↗

DNA Ploidy and Cell Cycle Analysis in Breast CancerSemantic proximity Read ↗

Tumour diploidy and survival in breast cancer patients with BRCA2 mutations.Semantic proximity Read ↗

BRCA2 in mitotic exit: a new role in regulating genomic stability.Semantic proximity Read ↗

BRCA2 heterozygosity delays cytokinesis in primary human fibroblasts.Semantic proximity Read ↗

Near-diploid hyperploidy in early breast cancer (T1a,b) is associated with higher risk of lymph node involvement.Semantic proximity Read ↗

The prognostic significance of determining DNA content in breast cancer by DNA image cytometry: the role of high grade aneuploidy in node negative breast cancerSemantic proximity Read ↗

Progressive Telomere Dysfunction Causes Cytokinesis Failure and Leads to the Accumulation of Polyploid CellsSemantic proximity Read ↗

Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.