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Article

Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification.

Current biology : CB - 7 Oct 1999

Tutt A, Gabriel A, Bertwistle D, Connor F, Paterson H, Peacock J, Ross G, Ashworth A

Abstract excerpt

Women heterozygous for mutations in the breast-cancer susceptibility genes BRCA1 and BRCA2 have a highly elevated risk of developing breast cancer [1]. BRCA1 and BRCA2 encode large proteins with no sequence similarity to one another. Although involvement in DNA repair and transcription has been s...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10531007
DOI: 10.1016/s0960-9822(99)80479-5

Genes

BRCA2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10531007-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification.PMID 10531007Read ↗

Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis.Semantic proximity Read ↗

A comprehensive analysis of BRCA2 gene: focus on mechanistic aspects of its functions, spectrum of deleterious mutations, and therapeutic strategies targeting BRCA2-deficient tumors.Semantic proximity Read ↗

BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination.Semantic proximity Read ↗

The Breast Cancer Susceptibility Gene BRCA2 Is Required for the Maintenance of Telomere HomeostasisSemantic proximity Read ↗

Suppression of polyploidy by the BRCA2 protein.Semantic proximity Read ↗

Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers.Semantic proximity Read ↗

Mechanisms underlying genome maintenance and tumour suppression by BRCA2Semantic proximity Read ↗

Phenotypic effects of heterozygosity for a BRCA2 mutation.Semantic proximity Read ↗

BRCA1/2 Haploinsufficiency: Exploring the Impact of Losing one Allele.Semantic proximity Read ↗

Tumorigenesis as a consequence of genetic instability in Brca1 mutant mice.Semantic proximity Read ↗

Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.Semantic proximity Read ↗

Tumour suppressor mechanisms in the control of chromosome stability: insights from BRCA2.Semantic proximity Read ↗

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