The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers.

doi:10.1073/pnas.0900571106

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Article

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jun 2009

Veeriah Selvaraju, Brennan Cameron, Meng Shasha, Singh Bhuvanesh, Fagin James A, Solit David B, Paty Philip B, Rohle Dan, Vivanco Igor, Chmielecki Juliann, Pao William, Ladanyi Marc, Gerald William L, Liau Linda, Cloughesy Timothy C, Mischel Paul S, Sander Chris, Taylor Barry, Schultz Nikolaus, Major John, Heguy Adriana, Fang Fang, Mellinghoff Ingo K, Chan Timothy A

Abstract excerpt

Tyrosine phosphorylation plays a critical role in regulating cellular function and is a central feature in signaling cascades involved in oncogenesis. The regulation of tyrosine phosphorylation is coordinately controlled by kinases and phosphatases (PTPs). Whereas activation of tyrosine kinases has been shown to play vital roles in tumor development, the role of PTPs is much less well defined. Here, we show that...

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Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Gene Expression Regulation, Neoplastic

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Share to Neoplasms

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Share to Receptor-Like Protein Tyrosine Phosphatases, Class 2

Share to STAT3 Transcription Factor

Source

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Identifiers

PMID: 19478061
DOI: 10.1073/pnas.0900571106
PMCID: PMC2687998

Genes

PTPRD
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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