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Single-cell and bulk sequencing analyses reveal the immune suppressive role of PTPN6 in glioblastoma

21 Sept 2023

Abstract excerpt

Glioblastoma (GBM) is a highly malignant brain cancer with a poor prognosis despite standard treatments. This investigation aimed to explore the feasibility of PTPN6 to combat GBM with immunotherapy. Our study employed a comprehensive analysis of publicly available datasets and functional experiments to assess PTPN6 gene expression, prognostic value, and related immune characteristics in glioma. We evaluated the...

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PMID: 37737713
DOI: 10.18632/aging.205052

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