Article
The Protein Tyrosine Phosphatase Receptor Delta Regulates Developmental Neurogenesis.
Cell reports - 7 Jan 2020
Tomita Hideaki, Cornejo Francisca, Aranda-Pino Begoña, Woodard Cameron L, Rioseco Constanza C, Neel Benjamin G, Alvarez Alejandra R, Kaplan David R, Miller Freda D, Cancino Gonzalo I
Abstract excerpt
PTPRD is a receptor protein tyrosine phosphatase that is genetically associated with neurodevelopmental disorders. Here, we asked whether Ptprd mutations cause aberrant neural development by perturbing neurogenesis in the murine cortex. We show that loss of Ptprd causes increases in neurogenic transit-amplifying intermediate progenitor cells and cortical neurons and perturbations in neuronal localization. These...
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