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Article

Loss-of-Function PTPRD Mutations Lead to Increased STAT3 Activation and Sensitivity to STAT3 Inhibition in Head and Neck Cancer.

PloS one - 1 Jan 2015

Peyser Noah D, Du Yu, Li Hua, Lui Vivian, Xiao Xiao, Chan Timothy A, Grandis Jennifer R

Abstract excerpt

BACKGROUND: Protein tyrosine phosphatase receptor type D (PTPRD) is a putative tumor suppressor in several cancers including head and neck squamous cell carcinoma (HNSCC). STAT3 is a frequently hyperactivated oncogene in HNSCC. As STAT3 is a direct substrate of PTPRD, we sought to determine the genetic or epigenetic alterations of PTPRD that contribute to overactive STAT3 in HNSCC. METHODS: We analyzed data from...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptor-Like Protein Tyrosine Phosphatases, Class 2

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Source

Open in PubMed Open full text

Identifiers

PMID: 26267899
DOI: 10.1371/journal.pone.0135750
PMCID: PMC4534317

Genes

PTPRD
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Loss-of-Function PTPRD Mutations Lead to Increased STAT3 Activation and Sensitivity to STAT3 Inhibition in Head and Neck Cancer.PMID 26267899Read ↗

Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer.Semantic proximity Read ↗

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers.Semantic proximity Read ↗

Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesisSemantic proximity Read ↗

PTPRD is homozygously deleted and epigenetically downregulated in human hepatocellular carcinomas.Semantic proximity Read ↗

Protein Tyrosine Phosphatases as Potential Regulators of STAT3 Signaling.Semantic proximity Read ↗

Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma.Semantic proximity Read ↗

Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma.Semantic proximity Read ↗

DKK3 is a potential tumor suppressor gene in papillary thyroid carcinomaSemantic proximity Read ↗

Receptor-type tyrosine-protein phosphatase κ directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphomaSemantic proximity Read ↗

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