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Article

Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma.

Cancer research - 15 Dec 2008

Solomon David A, Kim Jung-Sik, Cronin Julia C, Sibenaller Zita, Ryken Timothy, Rosenberg Steven A, Ressom Habtom, Jean Walter, Bigner Darell, Yan Hai, Samuels Yardena, Waldman Todd

Abstract excerpt

An additional tumor suppressor gene on chromosome 9p telomeric to the CDKN2A/B locus has long been postulated to exist. Using Affymetrix 250K single nucleotide polymorphism arrays to screen for copy number changes in glioblastoma multiforme (GBM), we detected a high frequency of deletions of the PTPRD gene, which encodes a receptor protein tyrosine phosphatase at chromosome 9p23-24.1. Missense and nonsense...

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Share to Chromosomes, Human, Pair 9
Share to Gene Silencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Glioblastoma

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Share to Oligonucleotide Array Sequence Analysis

Share to Receptor-Like Protein Tyrosine Phosphatases, Class 2

Share to Transplantation, Heterologous

Source

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Identifiers

PMID: 19074898
DOI: 10.1158/0008-5472.CAN-08-3272
PMCID: PMC2760967

Genes

PTPRD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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