Article
Bilateral renal-cell carcinoma associated with an acquired VHL mutation and long-term trichloroethylene exposure.
Clinical nephrology - 1 Jun 2009
Wells G M, Schroth W, Brauch H, Ross E A
Abstract excerpt
BACKGROUND/AIMS: The genetic basis for clear-cell renal carcinomas has been established in familial and many sporadic forms. Whether the latter can be induced by environmental carcinogens remains controversial, with concern over solvents such as trichloroethylene (TCE). To study this putative relationship, we analyzed the VHL gene from a patient with long-term TCE exposure. METHODS: PCR amplification and...
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