Article
Occupational exposure to organic solvents: a risk factor for pulmonary veno-occlusive disease.
The European respiratory journal - 1 Dec 2015
Montani David, Lau Edmund M, Descatha Alexis, Jaïs Xavier, Savale Laurent, Andujar Pascal, Bensefa-Colas Lynda, Girerd Barbara, Zendah Inès, Le Pavec Jerome, Seferian Andrei, Perros Frédéric, Dorfmüller Peter, Fadel Elie, Soubrier Florent, Sitbon Oliver, Simonneau Gérald, Humbert Marc
Abstract excerpt
Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension characterised by predominant remodelling of pulmonary venules. Bi-allelic mutations in the eukaryotic translation initiation factor 2α kinase 4 (EIF2AK4) gene were recently described as the major cause of heritable PVOD, but risk factors associated with PVOD remain poorly understood. Occupational exposures have been proposed as a...
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