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Article

Trichloroethylene exposure and specific somatic mutations in patients with renal cell carcinoma.

Journal of the National Cancer Institute - 19 May 1999

Brauch H, Weirich G, Hornauer M A, Störkel S, Wöhl T, Brüning T

Abstract excerpt

BACKGROUND: The development of renal cell carcinoma (RCC) has been associated with both genetic and environmental factors-with mutations in the von Hippel-Lindau (VHL) tumor suppressor gene for clear-cell RCC specifically and with long-term exposure to high doses of trichloroethylene (TRI), an industrially important solvent, for RCC generally. We investigated whether TRI exposure produces RCC through a specific...

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Share to Carcinoma, Renal Cell
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

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Share to Loss of Heterozygosity

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Source

Identifiers

PMID: 10340905
DOI: 10.1093/jnci/91.10.854

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Trichloroethylene exposure and specific somatic mutations in patients with renal cell carcinoma.PMID 10340905Read ↗

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