Occupational trichloroethylene exposure and renal carcinoma risk: evidence of genetic susceptibility by reductive metabolism gene variants.

doi:10.1158/0008-5472.CAN-09-4167

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Article

Occupational trichloroethylene exposure and renal carcinoma risk: evidence of genetic susceptibility by reductive metabolism gene variants.

Cancer research - 15 Aug 2010

Moore Lee E, Boffetta Paolo, Karami Sara, Brennan Paul, Stewart Patricia S, Hung Rayjean, Zaridze David, Matveev Vsevolod, Janout Vladimir, Kollarova Helena, Bencko Vladimir, Navratilova Marie, Szeszenia-Dabrowska Neonila, Mates Dana, Gromiec Jan, Holcatova Ivana, Merino Maria, Chanock Stephen, Chow Wong-Ho, Rothman Nathaniel

Abstract excerpt

Trichloroethylene (TCE) is a suspected renal carcinogen. TCE-associated renal genotoxicity occurs predominantly through glutathione S-transferase (GST) conjugation and bioactivation by renal cysteine beta-lyase (CCBL1). We conducted a case-control study in Central Europe (1,097 cases and 1,476 controls) specifically designed to assess risk associated with occupational exposure to TCE through analysis of detailed...

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PMID: 20663906
DOI: 10.1158/0008-5472.CAN-09-4167
PMCID: PMC2922418

Genes

GSTT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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