Article
No association of PGRN 3'UTR rs5848 in frontotemporal lobar degeneration.
Neurobiology of aging - 1 Apr 2011
Rollinson Sara, Rohrer Jonathan D, van der Zee Julie, Sleegers Kristel, Mead Simon, Engelborghs Sebastiaan, Collinge John, De Deyn Peter P, Mann David M A, Van Broeckhoven Christine, Pickering-Brown Stuart M
Abstract excerpt
Frontotemporal lobar degeneration (FTLD) is a highly familial neurodegenerative disease. It has been claimed that homozygosity of the SNP rs5848 located in the 3'UTR of progranulin increases risk for FTLD. We have attempted to replicate the association of rs5848 in three independent FTLD cohorts. No association of rs5848 with FTLD was observed in any individual cohort nor was any observed when the data was...
Read the complete abstract on PubMed