Association between GRN rs5848 polymorphism and Parkinson's disease in Taiwanese population.

doi:10.1371/journal.pone.0054448

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Association between GRN rs5848 polymorphism and Parkinson's disease in Taiwanese population.

PloS one - 1 Jan 2013

Chang Kuo-Hsuan, Chen Chiung-Mei, Chen Yi-Chun, Hsiao Ya-Chin, Huang Chin-Chang, Kuo Hung-Chou, Hsu Hsuan-Chu, Lee-Chen Guey-Jen, Wu Yih-Ru

Abstract excerpt

A single nucleotide polymorphism GRN rs5848 (3'UTR+78 C>T) was reported to alter the risk for frontotemporal lobar degeneration. Herein, we investigated the effect of GRN rs5848 on the risk of Parkinson's disease (PD) by genotyping 573 Taiwanese patients with PD and 490 age-matched control subjects. Compared to subjects with CC genotype, those with TT genotype had a 1.58-fold increased risk of PD (95% CI:...

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PMID: 23342160
DOI: 10.1371/journal.pone.0054448
PMCID: PMC3546937

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