Variation at GRN 3'-UTR rs5848 is not associated with a risk of frontotemporal lobar degeneration in Dutch population.

doi:10.1371/journal.pone.0007494

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Article

Variation at GRN 3'-UTR rs5848 is not associated with a risk of frontotemporal lobar degeneration in Dutch population.

PloS one - 22 Oct 2009

Simón-Sánchez Javier, Seelaar Harro, Bochdanovits Zoltán, Deeg Dorly J H, van Swieten John C, Heutink Peter

Abstract excerpt

BACKGROUND: A single nucleotide polymorphism (rs5848) located in the 3'- untranslated region of GRN has recently been associated with a risk of frontotemporal lobar degeneration (FTLD) in North American population particularly in pathologically confirmed cases with neural inclusions immunoreactive for ubiquitin and TAR DNA-binding protein 43 (TDP-43), but negative for tau and alpha-synuclein (FTLD-TDP)....

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PMID: 19847305
DOI: 10.1371/journal.pone.0007494
PMCID: PMC2761542

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