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Article

Growth stimulation leads to cellular senescence when the cell cycle is blocked.

Cell cycle (Georgetown, Tex.) - 1 Nov 2008

Demidenko Zoya N, Blagosklonny Mikhail V

Abstract excerpt

We tested a hypothesis that activation of growth-promoting pathways is required for cellular senescence. In the presence of serum, induction of p21 caused senescence, characterized by beta-Galactosidase staining, cell hypertrophy, increased levels of cyclin D1 and active TOR (target of rapamycin, also known as mTOR). Serum starvation and rapamycin inhibited TOR and prevented the expression of some senescent...

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Identifiers

PMID: 18948731
DOI: 10.4161/cc.7.21.6919

Genes

RPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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