Growth stimulation leads to cellular senescence when the cell cycle is blocked.

doi:10.4161/cc.7.21.6919

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Article

Growth stimulation leads to cellular senescence when the cell cycle is blocked.

Cell cycle (Georgetown, Tex.) - 1 Nov 2008

Demidenko Zoya N, Blagosklonny Mikhail V

Abstract excerpt

We tested a hypothesis that activation of growth-promoting pathways is required for cellular senescence. In the presence of serum, induction of p21 caused senescence, characterized by beta-Galactosidase staining, cell hypertrophy, increased levels of cyclin D1 and active TOR (target of rapamycin, also known as mTOR). Serum starvation and rapamycin inhibited TOR and prevented the expression of some senescent...

Topics

Cell Cycle
Cell Line
Cell Proliferation
Cell Shape
Cellular Senescence
Colony-Forming Units Assay
Cyclin D1
Cyclin-Dependent Kinase Inhibitor p21
Doxorubicin
Fibroblasts
Humans
Isopropyl Thiogalactoside
Models, Biological
Phenotype
Protein Kinases
Serum
Sirolimus
TOR Serine-Threonine Kinases

Source

Open in PubMed

Identifiers

PMID: 18948731
DOI: 10.4161/cc.7.21.6919

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