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Article

Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells

31 Jan 2019

Abstract excerpt

BACKGROUND AIMS: Delaying replicative senescence and extending lifespan of human mesenchymal stromal cells (MSCs) may enhance their potential for tissue engineering and cell based therapies. Accumulating evidence suggests that inhibitors of the mTOR signaling pathway, such as rapamycin, constitute promising pharmacological agents to retard senescence and extend stemness properties of various progenitor cell...

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PMID: 30703123
DOI: 10.1371/journal.pone.0204784

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