Article
A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme.
Nature - 14 Aug 2003
Dumoulin Mireille, Last Alexander M, Desmyter Aline, Decanniere Klaas, Canet Denis, Larsson Göran, Spencer Andrew, Archer David B, Sasse Jurgen, Muyldermans Serge, Wyns Lode, Redfield Christina, Matagne André, Robinson Carol V, Dobson Christopher M
Abstract excerpt
Amyloid diseases are characterized by an aberrant assembly of a specific protein or protein fragment into fibrils and plaques that are deposited in various organs and tissues, often with serious pathological consequences. Non-neuropathic systemic amyloidosis is associated with single point mutations in the gene coding for human lysozyme. Here we report that a single-domain fragment of a camelid antibody raised...
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