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Article

A Simple Analysis of the Second (Extra) Disulfide Bridge of VHHs.

Molecules (Basel, Switzerland) - 14 Oct 2024

Martins Carla, Gardebien Fabrice, Nadaradjane Aravindan Arun, Diharce Julien, de Brevern Alexandre G

Abstract excerpt

Camelids produce a special type of antibody, known as VHHs, that has lost the VL domain, providing a more optimised VH domain. This particular highly stable antibody domain has interesting properties for biotechnological development. Ordinarily, those molecules possess only one disulphide bridge, but surprisingly, at least a quarter of these VHHs have a second one. Curiously, this does not seem to be essential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39459230
DOI: 10.3390/molecules29204863
PMCID: PMC11509895

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