Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.

doi:10.1056/NEJMoa041974

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Article

Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.

The New England journal of medicine - 20 Jan 2005

Falini Brunangelo, Mecucci Cristina, Tiacci Enrico, Alcalay Myriam, Rosati Roberto, Pasqualucci Laura, La Starza Roberta, Diverio Daniela, Colombo Emanuela, Santucci Antonella, Bigerna Barbara, Pacini Roberta, Pucciarini Alessandra, Liso Arcangelo, Vignetti Marco, Fazi Paola, Meani Natalia, Pettirossi Valentina, Saglio Giuseppe, Mandelli Franco, Lo-Coco Francesco, Pelicci Pier-Giuseppe, Martelli Massimo F

Abstract excerpt

BACKGROUND: Nucleophosmin (NPM), a nucleocytoplasmic shuttling protein with prominent nucleolar localization, regulates the ARF-p53 tumor-suppressor pathway. Translocations involving the NPM gene cause cytoplasmic dislocation of the NPM protein. METHODS: We used immunohistochemical methods to study the subcellular localization of NPM in bone marrow-biopsy specimens from 591 patients with primary acute myelogenous...

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Identifiers

PMID: 15659725
DOI: 10.1056/NEJMoa041974

Genes

FLT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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